克罗米酚对男性低促性腺素性功能减退症必需

纽约（费希尔社健康版）1月末四日报道：据刊发在12月末出版的《受孕与子代》杂志的一项调查报告声称克罗米萘对大多较高促特质腺素高血压减退的女特质病征薄弱。来自伯明翰阿拉巴马大学的该调查报告的第一作者Scott J. WhittenClark在接纳费希尔通讯社采访问到：“临床表现或获得特质HH病征在接纳侵害特质更大和更加昂贵的治疗法（例如注射促特质腺激素类）前同步进行4个月末的克罗米萘试验特质治疗法是薄弱的。”WhittenClark和同事分析了克罗米萘对10名HH女特质病征（HH是导致女特质子代的常见因素）是否有效。调查报告称克罗米萘治疗法1年后，4名卡尔曼(氏)综合征病征中只有一名病征的受精卵浓度增加而全垂体新功能减退症病征的受精卵缺少患者皆没有得到优化。同样，该调查报告声称3名成年发病的临床表现HH女特质病征经过3个月末克罗米萘的治疗法受精卵浓度有了明显增加。即便如此该组病征已有两名恢复了受孕能力。WhittenClark说道：“除非对克罗米萘治疗法没有反应，我们不会因为阿司匹林停止对病征常用该类固醇。”最后作者总结说道：“因为条件更少，对HH病征促特质腺激素类类固醇和克罗米萘的随机分析难以同步进行，然而借助于多系列的严格选择标准对病征同步进行AO确实尽力促使测试克罗米萘恢复女特质较高受孕能力的有效特质。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

总编辑：蓝色幻想

总编辑： 张靖